题　目：

Mucosal associated invariant T cell-mediated vaccination and protection against pathogenic bacteria

主讲人：

王慧萌

主持人：

王忠芳 教授

时 间：

2019年 5月30日（星期四）下午15：00

地 点：

广州医科大学越秀校区16号楼五楼大会议室

讲座内容：

Mucosal Associated Invariant T (MAIT) cells are a subset of innate-like T cells, which are abundant in humans. They recognize antigens that are derived from bacterial riboflavin synthesis pathway metabolites, presented by highly conserved MHC-related 1 (MR1) molecules. Although the microbial reactivity of MAIT cells has been defined, their functions in protection against clinically important pathogens are unknown. Here, we demonstrate the protective role of MAIT cells in a murine pulmonary model with a human major pathogen, Legionella longbeachae. In response to infection, MAIT cells accumulate at the infection site and contribute to cytokine responses. In the absence of MAIT cells, MR1-/- mice display an impaired and delayed bacterial clearance. MAIT cell-mediated protection is more apparent when CD4+ T cells are removed and can be enhanced by prior expansion with synthetic antigens and an adjuvant (TLR agonists). Notably, adoptively transferred MAIT cells can provide highly immunodeficient Rag2-/-γC-/-mice with full protection against lethal L. longbeachae infection and this protection is achieved, at least in part, by IFN-γ production. In addition, through exploring the requirements for MAIT cell activation and expansion in vivo, the studies revealed that the pre-expanded MAIT cells in mice were potentially protective and to suggest that MAIT cells can be harnessed as a vaccine target to elicit a “memory”-type protection.

主讲人介绍：

王慧萌博士，现为王忠芳教授实验室博士后。于2009年至2013年在清华大学取得理学学士学位，于2014年至2018年在墨尔本大学取得免疫学博士学位，随后在墨尔本大学从事博士后工作至今。

欢迎对以上内容感兴趣的科研人员、临床医生、学生到场参加交流！敬请提前15分钟进场。

呼吸疾病国家重点实验室

广州呼吸健康研究院

国家呼吸系统疾病临床医学研究中心

广州医科大学附属第一医院

2019年5月30日