题　目：

Innate lymphoid cell differentiation – from a T cell perspective

主讲人：

James Philip DI SANTO (Director, Center for Translational Science, Institute Pasteur, Paris, France)

主持人：

莫家斌 教授

时　间：

2019年10月21日（星期一）下午3:00-5:00

地　点：

广州医科大学越秀校区16号楼五楼大会议室

内容介绍：

Innate lymphoid cells (ILCs) and natural killer (NK) cells have garnered considerable interest due to their functional properties in immune defense and tissue homeostasis. Our current understanding of how these development has been greatly facilitated by knowledge of T cell biology. Established models of T cell differentiation have provided the conceptual basis for a classification of ILCs and NK cells as innate homologues of adaptive T helper cells and cytotoxic T cells, respectively. Furthermore, NK cell and ILC activation finds parallels with known regulatory mechanisms within the T cell system. Here, I will examine the process of NK cell and ILC biology from a ‘T cell perspective’ in an attempt to extend the analogy between adaptive T cells and their innate ILC and NK cell counterparts.

主讲人介绍：

James Philip DI SANTO received a combined MD/PhD from Cornell Medical College and the Sloan Kettering Institute in NYC, pursued postdoctoral training with Pr Alain Fisher (Necker Hospital, Paris) and Pr Klaus Rajewsky (Institute for Genetics, Cologne) and has more than 30 years of experience in fundamental and translational immunology. The main interests of his laboratory at the Institute Pasteur (Paris) are in the areas of lymphocyte biology, cytokines, transcription factors and signaling pathways in the development and function of both adaptive (T and B cell) and innate lymphoid cells (ILC, NK cells) in mice and man. In parallel, over the last 20 years, they have developed a series of humanized mouse models for the immune system that allows them to probe fundamental questions in human immunology especially in relation to infectious diseases. While largely fundamental in nature, their projects have a translational aim to impact in the clinics.

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呼吸疾病国家重点实验室

国家呼吸系统疾病临床医学研究中心

2019年10月18日