题　目：

慢阻肺与哮喘的功能基因组研究

主讲人：

周小波教授

主持人：

郑则广教授

时　间：

2019年8月13日（星期二）上午10:00

地　点：

广州医科大学越秀校区16号楼五楼大会议室

讲座内容：

In this lecture, Dr. Zhou will use one of the most significant and well-replicated COPD GWAS loci at chr4q as an example to demonstrate biological insights we gleaned through understanding COPD GWAS loci. Our earlier work identified intergenic functional variants at the COPD GWAS locus near HHIP (hedgehog interacting protein) by demonstrating a chromatin loop between the DNA region spanning the functional variant and the promoter of HHIP. Subsequently, age-dependent spontaneous emphysema was identified in Hhip heterozygous mice that may involve increased oxidative stress and enhanced lymphocyte activation in Hhip+/- murine lungs. Increased lymphoid aggregates seen only in Hhip+/- mice not wild type control mice, resemble pathological changes in human COPD lungs. More and more evidence suggested that drugs that have genetic evidence supporting its mechanism usually have a higher successful rate in the clinical trials. We expect our translational genetic studies will eventually greatly expedite discoveries of novel drug targets to benefit COPD patients.

主讲人介绍：

哈佛医学院呼吸病学系副教授，布莱根妇女医院（Brigham and Women’s Hospital）功能遗传学和基因组学实验室（Functional Genetics and Genomics Laboratory）主任，美国人类遗传学学会、美国胸科学会和遗传基因组学学会委员，她的团队专注于破译与呼吸系统疾病主要是COPD和哮喘相关的人类基因组区域的功能，基于全基因组关联研究(GWAS) 或eQTL分析，再利用CRISPR/Cas-9基因编辑、单细胞RNA测序、3D-Organoid Culture系统及细胞和动物模型等手段，进而识别基因变异导致呼吸系统疾病易感的分子机制，近年来，团队先后在NEJM、JACI、AJRCCM、Lancet Respiratory、Human Molecular Genetics、PNAS等著名期刊上发表论文，成果丰硕。

欢迎对以上内容感兴趣的科研人员、临床医生、学生到场参加交流！敬请提前15分钟进场。

呼吸疾病国家重点实验室

广州呼吸健康研究院

国家呼吸系统疾病临床医学研究中心

广州医科大学附属第一医院

2019年8月6日